The phrase "resistance economy" was first introduced in 2010 by the leader of the revolution in the meeting of economic activists and entrepreneurs. In February 2013, the general policies of resilient economy were announced in 24 sections with flexible, optimistic, productive, intrinsic, progressive, and endogenous attitude by the leader of the revolution, which had been approved by the expeditious assembly. Resistance economics policies face barriers and challenges so that they have not yet succeeded in achieving the desired result. Therefore, the present research has identified barriers and challenges facing the resistance economy. Initially, using the literature of the subject and theoretical foundations and interviewing the economic experts, variables that seem to be obstacles to the realization of the resistance economy were extracted. Then, using the questionnaire, the required information was obtained from the viewpoint of university professors in the field of economics. Using exploratory factor analysis method, barriers to realization of resistance economy are classified in several factors. The method of verification of the factor analysis and the structural equation method of barriers to realization of resistance economy have been identified. The results showed that 44 initial classes in 12 factors or constructions are presented as barriers to the realization of a resilient economy. These 12 constituents, in order of priority, include cultural barriers, explanatory barriers, legal barriers, barriers to nature, financial corruption, democratic barriers, economic barriers, belief barriers, government structures, bureaucratic barriers, administrative barriers, and customs structures.